Testicular teratocarcinoma associated with testicular. These included major histocompatibility and embryonic antigens, chorionic gonadotropin, alpha fetoprotein, alkaline phosphatase. Late relapses of testicular germ cell tumor are uncommon. A series of clones was established after three serial clonings. It was recognized in the 1960s that testicular germ cell tumors were curable with chemotherapeutic drugs. They retain their ability to differentiate when reinjected into host animals. Testicular microlithiasis is a rare condition that has characteristic sonographic and histologic features. Teratocarcinoma in a non seminomatous, mixed germ cell.
Intrascrotal testicular torsion of a classical seminoma. Teratocarcinomas are germ cell cancers that fail to express antigens coded by. Teratocarcinoma definition of teratocarcinoma by the. Human testicular germ cell tumors in vitro springerlink. Highly differentiable teratocarcinoma cells were adapted to growth in tissue culture. A teratoma of lung is the most common type of germ cell tumor of the lung. Metastases to skin from occult malignant neoplasms. Geneva, switzerland 4, the term teratocarcinoma is mentioned only in passing. In addition, adenoviral vectors containing transgenes under the control of the flt1 promoter achieve very low levels of expression. An abdominal ct must be performed at least annually if teratoma is found in the retroperitoneum. These tumors comprise an undifferentiated embryonal carcinoma ec component and differentiated derivatives that can include all three germ layers.
This kind of mixed germ cell tumor may be known simply as a teratoma with elements of embryonal carcinoma or choriocarcinoma, or simply by. Desmin, myogenin, vimentin depending on type of sarcoma cytokeratin, epithelial membrane antigen if carcinoma virchows arch 2012. Intrascrotal testicular torsion as a presentation of malignancy is extremely rare especially in old age. Teratocarcinoma refers to a germ cell tumor that is a mixture of teratoma with embryonal carcinoma, or with choriocarcinoma, or with both. Pdf germ cell tumors of the testes represent a unique paradigm of diseases which can be. Pdf testicular teratocarcinoma associated with testicular.
He had a satisfactory response to dactinomycin actinomycin d therapy during the following 11 months. Teratoma of the testis is a type of testicular cancer affecting the germ cells of sperm. Pathology outlines teratoma with somatic type malignancy. You may not embed one of our images on your web page without a link back to our site. At a glance when a patient discovers a usually painless testicular mass, either. The patient was a 29yearold male with a right testicular mass, measuring 8. Cervical mature teratoma 17 years after initial treatment.
Three previously reported cases documented development of malignant germ cell tumor. The teratocarcinomaderived growth factor1 tdgf1 gene codes for a 188aminoacid glycoprotein that shares structural homology with the epidermal. Metastatic mature teratoma in lung following testicular. Germinal testicular neoplasms reported to occur in the horse include the seminoma, teratoma, teratocarcinoma, and embryonal carcinoma. Pure yolk sac tumor testicular teratocarcinoma associated with testicular microlithiasis article pdf available in abdominal imaging 332. Giant primary retroperitoneal teratoma in an adult. Guidelines for the diagnosis and staging of testicular cancer. Seminomas and nonseminomas are arguably the two most frequently encountered varieties of neoplastic lesions in the male gonads. Seminomatous tumors are the germ cell tumors composed of cells that resemble. Herein we report a case of late relapse in the left side of neck 17 years after treatment of left testicular teratocarcinoma. Retroperitoneal teratomas are rare and present challenging management options. We report a case of cervical mature teratoma appeared 17 years after treatment of testicular teratocarcinoma.
Teratocarcinoma as an ascitic tumor testicular teratomas. Simply select your manager software from the list below and click on download. They could also differentiate in solid tumors, confirming the multipotentiality of single teratocarcinoma cells. Testicular microlithiasisultrasonography teratocarcinoma of. Rhabdomyosarcoma in metastatic testicular germ cell tumor chondrosarcoma in metastatic testicular germ cell tumor. The present study examines the p53mediated responses in murine testicular teratocarcinoma cells exposed to the drug. Understanding the molecular biology of tgct could help improve treatment of other cancers. The incidence of cervical metastasis in testicular germ cell tumor is about 5%. An update to the trials available for the teratoma.
Teratocarcinoma is a form of malignant germ cell tumor that occurs in both animals and humans. T1 metastatic mature teratoma in lung following testicular embryonal carcinoma and teratocarcinoma. Testicular teratocarcinoma testicular embryonal carcinoma. Germ cell tumors also exhibit a unique biology and genetics that distinguish them from other solid tumors and might contribute to their. Eighton, 1954, while studying animal in tumors in vitro, converted a teratoma of the ovary of a mouse to an ascitic form and ultimately. In vitro growth and differentiation of clonal populations. Teratomas are tumors composed of tissues derived from more than one germ cell line. If you would like a large, unwatermarked image for your web page or.
Testicular microlithiasis associated with teratocarcinoma. N2 we report seven cases of metastatic mature teratoma in the lung from testicular teratocarcinoma and embryonal carcinoma. They are generally benign and rarely spread to nearby tissues. Teratocarcinoma definition of teratocarcinoma by medical. Testicular cancers respond favorably to chemotherapy with the platinumcontaining drug cis diamminedichloroplatinumii cisplatin. Teratomas are bizarre neoplasms derived from embryonic tissues that are typically found only in the gonadal and sacrococcygeal regions of adults. Mature teratomas are tumors formed by cells similar to cells of adult tissues.
The patient had elevated levels of chorionic gonadotropin hormone in his urine. Thomson, in essentials of stem cell biology third edition, 2014. Teratoma definition of teratoma by medical dictionary. Testicular teratocarcinoma with intracaval metastases to. A 20 year old patient underwent left sided orchiectomy followed by systemic therapy and retroperitoneal residual mass resection in 1989. We report a case of testicular teratocarcinoma involving the inferior vena cava with extension to the right atrium and metastases to the tricuspid valve. The terminology of teratocarcinomas and teratomas nature. Metastatic teratocarcinoma following chemotherapy chest. Most common malignancy in men in the 15 to 35 year age group. Benign lesions represent a greater percentage of cases in children than in adults.
It is often associated with premalignant changes and malignant neoplasms of the testes. Testicular teratocarcinoma associated with testicular microlithiasis article pdf available in abdominal imaging 332. Pathology of germ cell tumors of the testis patologi. The basis in the medical literature for this postulate is detailed. Teratomas are germ cell tumors that when seen under the microscope, look like each of the three layers of a developing embryo. Pulmonary teratomas are rare and commonly involve the upper lobe of the left lung. Expression of teratocarcinomaderived growth factor1. Germ cells are precursors to sperm cells that will eventually transform into sperms the testes are the male reproductive organs, equivalent to the ovaries in women.
A case of testicular teratocarcinoma metastatic to a mediastinal lymph node and associated with a mediastinal lesion indistinguishable from an enteric cyst is presented. Testicular germ cell tumor gct is the most commonly diagnosed cancer among young adult men, with rates peaking in the 3039 age group. Testicular germcell tumours tgcts represent the model of a curable malignancy. If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Testicular torsion is defined as a rotation of the testis around the longitudinal axis of the spermatic cord, resulting in obstruction of testicular blood flow, which accounts for 54% of acute scrotal disease. Testicular cancer is one of the few neoplasms associated with accurate serum markers. The incidence of testicular tumours in asia is only 0. We believe this to be the first such reported case. Fatherson testicular teratocarcinomamalignancy urology. In germ cell tumour, metastatic disease first involves the retroperitoneal lymph nodes, then the tumor spreads via thoracic duct to the. Among these, a common form is teratoma with endodermal sinus tumor.
In the recent consensus book on human testicular tumors compiled by the experts of the world health organization who. A teratocarcinoma is composed of undifferentiated stem cells and their more differentiated derivatives. Difference between seminoma and nonseminoma compare the. Criteria for pulmonary origin are the exclusion of a gonadal or other extragonadal primary site and origin entirely within the lung. Testicular tumors can be categorized into different subgroups based on their characteristic morphological features. A comparative study of eight cell lines derived from human. Mixed germ cell tumours are the second most common testicular germ cell tumours following seminomas and they account for 4045% of all the primary testicular gcts. Until recently, human testicular germ cell tumors were studied primarily by examination of surgical specimens, and many ideas about their biology are predicated on data from the mouse teratocarcinoma system, which has been developed and exploited.
Eight independent cell lines, derived from human testicular germ. We report here the case of a histologically unusual retroperitoneal tumor detected on computed tomography during the workup of abdominal pain in a 32yearold male. Bilateral testicular leiomyosarcoma in a stallion neil. H congenital anomalies of the testis, in campbells urology, philadelphia. One factor that could explain the efficacy of cisplatin is the low frequency of p53 mutations observed in this tumor type. Wed like to understand how you use our websites in order to improve them. However, the lung is a very uncommon site for such a tumor, and hence, the origin of the teratoma from other common sites such as gonads should be eliminated prior to establishing a diagnosis of. A patient had cutaneous metastases arising from a testicular teratocarcinoma. From the departments of urology, surgery, and radiology, tzlane university, new orleans, louisiana abstractwe report a case of testicular teratocarcinoma involving the inferior vena cava with extension to the right atrium and. Ppt testicular tumors powerpoint presentation free to. It is postulated that the mediastinal enteric cystlike lesion resulted from histologic maturation of metastatic teratocarcinoma after intensive chemotherapy.
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